The drug-binding activity of the multidrug-responding transcriptional regulator BmrR resides in its C-terminal domain

被引：33

作者：

Markham, PN ^{[1
]}

Ahmed, M ^{[1
]}

Neyfakh, AA ^{[1
]}

机构：

[1] UNIV ILLINOIS,DEPT MED CHEM & PHARMACOGNOSY,CHICAGO,IL 60612

来源：

JOURNAL OF BACTERIOLOGY | 1996年 / 178卷 / 05期

关键词：

D O I：

10.1128/jb.178.5.1473-1475.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rhodamine and tetraphenylphosphonium, the substrates of the Bacillus subtilis multidrug efflux transporter Bmr, induce the expression of Bmr through direct interaction with its transcriptional activator BmrR. Here we show that the C-terminal domain of BmrR, expressed individually, binds both these compounds and therefore can be used as a model for molecular analysis of the phenomenon of multidrug recognition.

引用

页码：1473 / 1475

页数：3

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