Complement driven by conformational changes

被引:233
作者
Gros, Piet [1 ]
Milder, Fin J. [1 ]
Janssen, Bert J. C. [1 ]
机构
[1] Univ Utrecht, Fac Sci, Bijvoet Ctr Biomol Res, NL-3584 CH Utrecht, Netherlands
关键词
D O I
10.1038/nri2231
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Complement in mammalian plasma recognizes pathogenic, immunogenic and apoptotic cell surfaces, promotes inflammatory responses and marks particles for cell lysis, phagocytosis and B-cell stimulation. At the heart of the complement system are two large proteins, complement component C3 and protease factor B. These two proteins are pivotal for amplification of the complement response and for labelling of the target particles, steps that are required for effective clearance of the target. Here we review the molecular mechanisms of complement activation, in which proteolysis and complex formation result in large conformational changes that underlie the key offensive step of complement executed by C3 and factor B. Insights into the mechanisms of complement amplification are crucial for understanding host defence and pathogen immune evasion, and for the development of complement-immune therapies.
引用
收藏
页码:48 / 58
页数:11
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