cis-{Pt(NH3)2(L)}2+/+ (L = Cl, H2O, NH3) binding to purines and CO:: Does π-back-donation play a role?

被引：18

作者：

Baik, MH ^{[1
]}

Friesner, RA

Lippard, SJ

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

[2] Indiana Univ, Sch Informat, Bloomington, IN 47405 USA

[3] Columbia Univ, Dept Chem, New York, NY 10027 USA

[4] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

INORGANIC CHEMISTRY | 2003年 / 42卷 / 26期

关键词：

D O I：

10.1021/ic035022b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The ability of cis-{Pt(NH3)(2)(L)}(2+/+), a molecular fragment of the anticancer drug cisplatin, to bind to purines and CO by pi-back-donation from Pt to the ligand was examined computationally. Optimized geometries and computed vibrational frequencies suggest that cis-{Pt(NH3)(2)(L)}(2+/+) (L = Cl, H2O, NH3) is a poor g-donor and that pi-back-donation does not play an important role for Pt(II)-ligand interactions in general.

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页码：8615 / 8617

页数：3

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