Tissue-Specific Stem Cells: Lessons from the Skeletal Muscle Satellite Cell

被引：383

作者：

Brack, Andrew S. ^{[1
,2
,3
]}

Rando, Thomas A. ^{[4
,5
,6
,7
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[4] Stanford Univ, Sch Med, Paul F Glenn Labs Biol Aging, Stanford, CA 94305 USA

[5] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[6] Vet Affairs Palo Alto Hlth Care Syst, Neurol Serv, Palo Alto, CA 94304 USA

[7] Vet Affairs Palo Alto Hlth Care Syst, Rehabil Res & Dev Ctr Excellence, Palo Alto, CA 94304 USA

来源：

CELL STEM CELL | 2012年 / 10卷 / 05期

关键词：

TEMPLATE DNA STRANDS; SELF-RENEWAL; PROGENITOR CELLS; UP-REGULATION; MOUSE; PAX7; MAINTENANCE; MYOGENESIS; GROWTH; MYOD;

D O I：

10.1016/j.stem.2012.04.001

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

In 1961, the satellite cell was first identified when electron microscopic examination of skeletal muscle demonstrated a cell wedged between the plasma membrane of the muscle fiber and the basement membrane. In recent years it has been conclusively demonstrated that the satellite cell is the primary cellular source for muscle regeneration and is equipped with the potential to self renew, thus functioning as a bona fide skeletal muscle stem cell (MuSC). As we move past the 50th anniversary of the satellite cell, we take this opportunity to discuss the current state of the art and dissect the unknowns in the MuSC field.

引用

收藏

页码：504 / 514

页数：11

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