Identification and biological activity of microbial metabolites of xanthohumol

被引：27

作者：

Herath, W

Ferreira, D

Khan, SI

Khan, IA ^{[1
]}

机构：

[1] Univ Mississippi, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 11期

关键词：

xanthohumol; microbial metabolite; chalcone; NMR; antimalarial;

D O I：

10.1248/cpb.51.1237

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Microbial transformation of xanthohumol using the culture broth of Cunninghamella echinulata NRRL 3655 afforded (2S)-8-[4"-hydroxy-3"-methyl-(2"-Z)-butenyl]-4',7-dihydroxy-5-methoxyflavanone (5) and (2s)-8-[5"-hydroxy-3"-methyl-(2"-E)-butenyl]-4',7-dihydroxy-5-methoxyflavanone (6). Xanthohumol (1) and flavanone 6 as well as (E)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2",3":4',3']-2',4-dihydroxy-6'-methoxychalcone (2), (2S)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2"',3":7,8]-4'-hydroxy-5-methoxyflavanone (3) obtained with Pichia membranifaciens showed antimalarial activity against Plasmodium falciparum.

引用

页码：1237 / 1240

页数：4

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