Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

被引：96

作者：

Olson, S

Aster, SD

Brown, K

Carbin, L

Graham, DW

Hermanowski-Vosatka, A

LeGrand, CB

Mundt, SS

Robbins, MA

Schaeffer, JM

Slossberg, LH

Szymonifka, MJ

Thieringer, R

Wright, SD

Balkovec, JM

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Atherosclerosis & Endocrinol, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 19期

关键词：

11; beta-HSD1; adamantyl triazole; metabolic syndrome;

D O I：

10.1016/j.bmcl.2005.06.040

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Adamantyl triazoles were identified as selective inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). They are active both in in vitro and in in vivo pharmacodynamic models. The synthesis and structure-activity relationships of these inhibitors are presented. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：4359 / 4362

页数：4

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