Mitochondria: pharmacological manipulation of cell death

被引：158

作者：

Bouchier-Hayes, L ^{[1
]}

Lartigue, L ^{[1
]}

Newmeyer, DD ^{[1
]}

机构：

[1] Jolla Immunol Allergy & Immunol, Dept Cellular Immunol, San Diego, CA 92121 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 10期

关键词：

D O I：

10.1172/JCI26274

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.

引用

页码：2640 / 2647

页数：8

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