Is beta-APP a marker of axonal damage in short-surviving head injury?

被引：151

作者：

McKenzie, KJ

McLellan, DR

Gentleman, SM

Maxwell, WL

Gennarelli, TA

Graham, DI

机构：

[1] UNIV GLASGOW,SO GEN HOSP,INST NEUROL SCI,DEPT NEUROPATHOL,NHS TRUST,GLASGOW G51 4TF,LANARK,SCOTLAND

[2] CHARING CROSS & WESTMINSTER MED SCH,DEPT ANAT,LONDON W6 8RF,ENGLAND

[3] UNIV GLASGOW,LAB HUMAN ANAT,GLASGOW G51 4TF,LANARK,SCOTLAND

[4] MED COLL PENN & HAHNEMANN UNIV,DEPT NEUROSURG,PHILADELPHIA,PA

来源：

ACTA NEUROPATHOLOGICA | 1996年 / 92卷 / 06期

关键词：

head injury; axonal bulbs; beta-amyloid precursor protein (beta-APP); immunocytochemistry; diffuse axonal injury;

D O I：

10.1007/s004010050568

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

beta-Amyloid precursor protein (beta-APP), a normal constituent of neurons which is conveyed by fast a axonal transport, has been found to be a useful marker for axonal damage in cases of fatal head injury. Immunocytochemistry or beta-APP is a more sensitive technique for identifying axonal injury than conventional silver impregnation, This study was designed to determine how quickly evidenc of axonal damage and bulb formation appears. Using this method a variety of brain areas were studied from 55 patients who died within 24 h of a head injury, Immunocytochemical evidence of axonal injury was first detected after 2 h survival, axonal bulbs were first identified after 3 h survival, and the amount of axonal damage and axonal bulb formation increased the longer the survival time.

引用

页码：608 / 613

页数：6

共 25 条

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