Binding of naphthyridine carbamate dimer to the (CGG)n repeat results in the disruption of the G-C base pairing

被引：74

作者：

Peng, T ^{[1
]}

Nakatani, K ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Ibaraki 5670047, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 44期

关键词：

DNA cleavage; mass spectrometry; nucleotides;

D O I：

10.1002/anie.200502282

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A disruptive influence: The naphthyridine carbamate dimer (NC) binds to the CGG/ CGG triad with an exclusive 2:1 stoichiometry. A DNA oligomer is selectively cleaved at the site of cytosine in the triad upon treatment of the NC-bound CGG/ CGG triad with hydroxylamine and hot piperidine (see picture; red: 2-amino-1,8-naphthyridine, blue: cytosine). The 2:1 NC-CGG/CGG complex is also produced in the (CGG)n repeat. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：7280 / 7283

页数：4

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