How do small single-domain proteins fold?

被引：824

作者：

Jackson, SE ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

FOLDING & DESIGN | 1998年 / 3卷 / 04期

关键词：

D O I：

10.1016/S1359-0278(98)00033-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many small, monomeric proteins fold with simple two-state kinetics and show wide variation in folding rates, from microseconds to seconds. Thus, stable intermediates are not a prerequisite for the fast, efficient folding of proteins and may in fact be kinetic traps and slow the folding process. Using recent studies, can we begin to search for trends which may lead to a better understanding of the protein folding process?

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页码：R81 / R91

页数：11

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