Trophic actions of GABA on neuronal development

被引:365
作者
Represa, A [1 ]
Ben-Ari, Y [1 ]
机构
[1] INSERM, U29, INMED, Marseille, France
关键词
D O I
10.1016/j.tins.2005.03.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
During brain development, transmitter-gated receptors are operative before synapse formation, suggesting that their action is not restricted to synaptic transmission. GABA, which is the principal excitatory transmitter in the developing brain, acts as an epigenetic factor to control processes including cell proliferation, neuroblast migration and dendritic maturation. These effects appear to be mediated through a paracrine, diffuse, non-synaptic mode of action that precedes the more focused, rapid mode of operation characteristic of synaptic connections. This sequential operation implies that GABA is used as an informative agent but in a unique context at an early developmental stage. This sequence also implies that by altering these effects, drugs acting on the GABA system could be pathogenic during pregnancy.
引用
收藏
页码:278 / 283
页数:6
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