Palladium-Catalyzed Oxidative Trifluoromethylation of Indoles at Room Temperature

被引：204

作者：

Mu, Xin ^{[1
]}

Chen, Shujun ^{[2
]}

Zhen, Xingliang ^{[2
]}

Liu, Guosheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[2] Changsha Univ Sci & Technol, Dept Chem, Changsha 410114, Hunan, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 22期

关键词：

homogeneous catalysis; indoles; oxidation; palladium; trifluoromethylation; FRIEDEL-CRAFTS ALKYLATION; CROSS-COUPLING REACTIONS; ASYMMETRIC FLUORINATION; REDUCTIVE ELIMINATION; CONVENIENT METHOD; ORGANIC HALIDES; REACTIVITY; CHEMISTRY; PERFLUOROALKYL; STRATEGIES;

D O I：

10.1002/chem.201100283

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incorporation of fluorine atoms into organic molecules significantly enhances many of their properties, such as solubility, metabolic stability, and bioavailability. Among organofluorine molecules, trifluoro ACHTUNGTRENUNGmethylated compounds play a unique and important role in agricultural and medicinal chemistry.[2] As a consequence, the exploitation of efficient methods to construct C-CF3 bond has received much attention. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6039 / 6042

页数：4

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