Bu4NI-Catalyzed C-O Bond Formation by Using a Cross-Dehydrogenative Coupling (CDC) Reaction

被引：273

作者：

Chen, Long ^{[1
]}

Shi, Erbo ^{[1
]}

Liu, Zhaojun ^{[1
]}

Chen, Shulin ^{[1
]}

Wei, Wei ^{[1
]}

Li, Hong ^{[1
]}

Xu, Kai ^{[1
]}

Wan, Xiaobing ^{[1
,2
]}

机构：

[1] Soochow Suzhou Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 15期

基金：

中国国家自然科学基金;

关键词：

carboxylic acids; cross-coupling; ethers; oxidation; reaction mechanisms; H BOND; OXIDATIVE ALKYLATION; CATALYZED AMIDATION; PRINS CYCLIZATIONS; DIRECT ARYLATION; ALPHA-ARYLATION; BENZYL ETHERS; ACTIVATION; FUNCTIONALIZATION; ACID;

D O I：

10.1002/chem.201100192

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The crème de la crème! A practical and simple Bu 4NI-catalyzed C-O bond formation was achieved by using a cross-dehydrogenative coupling (CDC) reaction with tert-butyl hydroperoxide (TBHP) as the ultimate oxidant (see scheme; R1=aryl, heteroaryl, alkyl; R2, R3=alkyl, alkyl halide). This approach is the most straightforward method to date for the synthesis of α-acyloxy ethers. A plausible mechanism has been proposed. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4085 / 4089

页数：5

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