Self-regulating gene: An exact solution

被引:207
作者
Hornos, JEM [1 ]
Schultz, D
Innocentini, GCP
Wang, J
Walczak, AM
Onuchic, JN
Wolynes, PG
机构
[1] Univ Calif San Diego, Ctr Theoret Biol Phys, La Jolla, CA 92093 USA
[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
[3] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA
来源
PHYSICAL REVIEW E | 2005年 / 72卷 / 05期
关键词
D O I
10.1103/PhysRevE.72.051907
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
An exact steady-state solution of the stochastic equations governing the behavior of a gene regulated by a self-generated proteomic atmosphere is presented. The solutions depend on an adiabaticity parameter measuring the relative rate of DNA-protein unbinding and protein degradation. The steady-state solution reveals deviations from the commonly used Ackers approximation based on the equilibrium law of mass action, allowing anticooperative behavior in the "nonadiabatic" limit of slow binding and unbinding rates. Noise from binding and unbinding events dominates the shot noise of protein synthesis and degradation up to quite high values of the adiabaticity parameter.
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页数:5
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