Sparks Fly in PGE2-Modulated Macrophage Polarization

被引：19

作者：

Franco, Fabien ^{[1
,2
]}

Wenes, Mathias ^{[1
,2
]}

Ho, Ping-Chih ^{[1
,2
]}

机构：

[1] Univ Lausanne, Dept Fundamental Oncol, Lausanne, Switzerland

[2] Univ Lausanne, Ludwig Canc Res, Epalinges, Switzerland

来源：

IMMUNITY | 2018年 / 49卷 / 06期

关键词：

ACTIVATION; CELL;

D O I：

10.1016/j.immuni.2018.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

How macrophages convey extracellular signals by bridging metabolism and functions remains unclear. In this issue of Immunity, Sanin et al. (2018) report that prostaglandin E2 (PGE2) treatment in interleukin-4-activated macrophages suppresses mitochondrial membrane potential to control voltage-regulated genes involved in proliferation and immune responses.

引用

页码：987 / 989

页数：3

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