Leptin Does Not Directly Affect CNS Serotonin Neurons to Influence Appetite

被引：58

作者：

Lam, Daniel D. ^{[1
]}

Leinninger, Gina M. ^{[6
]}

Louis, Gwendolyn W. ^{[6
]}

Garfield, Alastair S. ^{[1
]}

Marston, Oliver J. ^{[1
]}

Leshan, Rebecca L. ^{[6
]}

Scheller, Erica L. ^{[7
]}

Christensen, Lyndsay ^{[6
]}

Donato, Jose, Jr. ^{[8
]}

Xia, Jing ^{[2
,3
]}

Evans, Mark L. ^{[5
]}

Elias, Carol ^{[8
]}

Dalley, Jeffrey W. ^{[2
,3
,4
]}

Burdakov, Denis I. ^{[1
]}

Myers, Martin G., Jr. ^{[6
]}

Heisler, Lora K. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1PD, England

[2] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 1PD, England

[3] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 1PD, England

[4] Univ Cambridge, Dept Psychiat, Cambridge CB2 1PD, England

[5] Univ Cambridge, Inst Metab Sci, Cambridge CB2 1PD, England

[6] Univ Michigan, Div Metab Endocrinol & Diabet, Dept Internal Med, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Sch Dent, Ann Arbor, MI 48109 USA

[8] Univ Texas SW Med Ctr Dallas, Div Hypothalam Res, Dept Internal Med, Dallas, TX 75390 USA

来源：

CELL METABOLISM | 2011年 / 13卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

ARCUATE NUCLEUS NEURONS; 5-HT2C RECEPTOR; MICE; INHIBITION; ACTIVATION; DELETION; TARGETS; OB/OB; BRAIN;

D O I：

10.1016/j.cmet.2011.03.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not express LepRb. Indeed, while leptin hyperpolarizes some non-5-HT DR neurons, leptin does not alter the activity of DR 5-HT neurons. Furthermore, 5-HT depletion does not impair the anorectic effects of leptin. The serotonin transporter-cre allele (Sert(cre)) is expressed in 5-HT (and developmentally in some non-5-HT) neurons. While Sert(cre) promotes LepRb excision in a few LepRb neurons in the hypothalamus, it is not active in DR LepRb neurons, and neuron-specific Sert(cre)-mediated LepRb inactivation in mice does not alter body weight or adiposity. Thus, leptin does not directly influence 5-HT neurons and does not meaningfully modulate important appetite-related determinants via 5-HT neuron function.

引用

页码：584 / 591

页数：8

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