OVEREXPRESSION OF B7-H4 IN TUMOR INFILTRATED DENDRITIC CELLS

被引：53

作者：

Cheng, Chen ^{[1
,2
]}

Qu, Qiu-Xia ^{[2
]}

Shen, Yu ^{[2
]}

Lv, Yan-Tian ^{[1
]}

Zhu, Yi-Bei ^{[3
]}

Zhang, Xue-Guang ^{[2
,3
]}

Huang, Jian-An ^{[1
,2
]}

机构：

[1] Soochow Univ, Resp Dept, Affiliated Hosp 1, Suzhou 215006, Peoples R China

[2] Soochow Univ, Clin Immunol Lab, Affiliated Hosp 1, Suzhou 215006, Peoples R China

[3] Soochow Univ, Biotechnol Res Inst, Suzhou 215006, Peoples R China

来源：

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY | 2011年 / 32卷 / 04期

基金：

中国国家自然科学基金;

关键词：

B7-H4; cancer microenvironment; dendritic cells; T cell; REGULATORY T-CELLS; ANTITUMOR IMMUNE-RESPONSE; EXPRESSION; CANCER; CARCINOMA; DIFFERENTIATION; SURVIVAL; INHIBITION; ACTIVATION; MOLECULE;

D O I：

10.1080/15321819.2011.578190

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

DCs infiltrated tumors appears to be phenotypically and functionally defective. B7-H4 was highlighted for its inhibitory role in T cell responses. In this study, we showed that B7-H4 was moderately expressed in imDCs, and up-regulated by IL-10, and TNF-alpha could counteract the up-regulatory effects of IL-10 on expression of B7-H4 in DCs in vitro. Furthermore, tumor infiltrated DCs expressed B7-H4 at high levels. Blockade of B7-H4 expressed in DCs highly resulted in enhanced T cell proliferation and IFN-gamma production significantly. Otherwise, the high level of IL-10 and TNF-a was both detected in the tumor, which suggested that TNF-a can not antagonize the effects of IL-10 on expression of B7-H4 in DCs in vivo. These data indicate that tumor environment may condition local DCs to become dysfunctional in the phenotype, and that the high expression of B7-H4 may contribute to the tumor infiltrated DCs to mediate immune invasion.

引用

页码：353 / 364

页数：12

共 27 条

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Detection of b7-H4 and p53 in pancreatic cancer - Potential role as a cytological diagnostic adjunct [J].