The concept of typical and atypical chronic lymphocytic leukaemia

被引:51
作者
Criel, A [1 ]
Michaux, L [1 ]
De Wolf-Peeters, C [1 ]
机构
[1] AZ St Jan Brugge, Dept Haematol, B-8000 Brugge, Belgium
关键词
chronic lymphocytic leukaemia; typical CLL; atypical CLL; immunophenotype; clinical features; prognosis; cytogenetics;
D O I
10.3109/10428199909093723
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Subdivision of CLL into typical and atypical subtypes, as proposed by the FAB group in 1989, is not yet widely accepted and its clinical significance is still debated. In recent years, however, a strong correlation was found between atypical morphology, trisomy 12 and an aberrant immunophenotype. In the first part of this review we discuss current concepts and generally accepted data on morphology, immunophenotype, genetic abnormalities, clinical features and prognostic factors in CLL. Subsequently, based on our own series and other recently published data, we analyse the validity and clinical impact of classifying CLL into typical and atypical entities and demonstrate that they may represent two closely related but different entities.
引用
收藏
页码:33 / +
页数:14
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