Putting the stress on senescence

被引：333

作者：

Serrano, M ^{[1
]}

Blasco, MA ^{[1
]}

机构：

[1] CSIC, Natl Biotechnol Ctr, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(00)00278-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cultivation of primary cells over many generations eventually results in a reproducible loss of proliferative potential that has been termed 'replicative senescence' . Recent work has revealed the heterogeneity of senescence. Importantly, the analysis of the various aspects and types of senescence has turned out to be very informative about numerous in vivo processes, and particularly about carcinogenesis.

引用

页码：748 / 753

页数：6

共 63 条

[1] Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a [J].

Alani, RM ;

Young, AZ ;

Shifflett, CB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) :7812-7816

[2] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[3] Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].

Blasco, MA ;

Lee, HW ;

Hande, MP ;

Samper, E ;

Lansdorp, PM ;

DePinho, RA ;

Greider, CW .

CELL, 1997, 91 (01) :25-34

[4]

Blasco Maria A., 1999, Genes and Development, V13, P2353, DOI 10.1101/gad.13.18.2353

[5] Extension of life-span by introduction of telomerase into normal human cells [J].

Bodnar, AG ;

Ouellette, M ;

Frolkis, M ;

Holt, SE ;

Chiu, CP ;

Morin, GB ;

Harley, CB ;

Shay, JW ;

Lichtsteiner, S ;

Wright, WE .

SCIENCE, 1998, 279 (5349) :349-352

[6] Tumor suppressors and oncogenes in cellular senescence [J].

Bringold, F ;

Serrano, M .

EXPERIMENTAL GERONTOLOGY, 2000, 35 (03) :317-329

[7] p16INK4A and p19ARF act in overlapping pathways in cellular immortalization [J].

Carnero, A ;

Hudson, JD ;

Price, CM ;

Beach, DH .

NATURE CELL BIOLOGY, 2000, 2 (03) :148-155

[8] p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis [J].

Chin, L ;

Artandi, SE ;

Shen, Q ;

Tam, A ;

Lee, SL ;

Gottlieb, GJ ;

Greider, CW ;

DePinho, RA .

CELL, 1999, 97 (04) :527-538

[9] Expression of senescence-associate beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia [J].

Choi, J ;

Shendrik, I ;

Peacocke, M ;

Peehl, D ;

Buttyan, R ;

Ikeguchi, EF ;

Katz, AE ;

Benson, MC .

UROLOGY, 2000, 56 (01) :160-166

[10] Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions [J].

Dannenberg, JH ;

van Rossum, A ;

Schuijff, L ;

Riele, HT .

GENES & DEVELOPMENT, 2000, 14 (23) :3051-3064

← 1 2 3 4 5 6 7 →