Transient Micromotors That Disappear When No Longer Needed

被引:133
作者
Chen, Chuanrui [1 ,2 ]
Karshalev, Emil [1 ]
Li, Jinxing [1 ]
Soto, Fernando [1 ]
Castillo, Roxanne [1 ]
Campos, Isaac [1 ]
Mou, Fangzhi [2 ]
Guan, Jianguo [2 ]
Wang, Joseph [1 ]
机构
[1] Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA
[2] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
基金
中国国家自然科学基金;
关键词
transient; micromotor; biocompatible; controlled degradation; DRUG-DELIVERY; JANUS MICROMOTORS; ZINC-OXIDE; DRIVEN; NANOPARTICLES; DEGRADATION; ELECTRONICS; SCIENCE; PROTEIN; MOTORS;
D O I
10.1021/acsnano.6b06256
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
Transient self-destroyed micromotors that autonomously disappear in biological media at controlled rates upon completing their task, without leaving a toxic residue, are presented. The propulsion and degradation characteristics of the self-destroyed Mg/ZnO, Mg/Si, and Zn/Fe Janus micromotors and single component Zn micromotors are described. The degradation of the Janus micromotors relies on the different corrosion rates of their core shell components. Inductively coupled plasma optical emission spectrometry measurements are used to probe the time-dependent degradation of the different constituents of the micromotors. The toxicity of the transient micromotors is discussed toward their potential use in biomedical applications. This concept of transient micromotors offers considerable potential for diverse practical applications in the near future.
引用
收藏
页码:10389 / 10396
页数:8
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