The effects of atrial natriuretic peptide (ANP(1-28)) on corticotropin releasing factor in brain of rats

被引：11

作者：

Biro, E

Gardi, J

Vecsernyes, M

Julesz, J

Toth, G

Telegdy, G

机构：

[1] ALBERT SZENT GYORGYI MED UNIV,DEPT PATHOPHYSIOL,H-6701 SZEGED,HUNGARY

[2] ALBERT SZENT GYORGYI MED UNIV,DEPT MED 1,ENDOCRINE UNIT,H-6701 SZEGED,HUNGARY

[3] ALBERT SZENT GYORGYI MED UNIV,DEPT MED CHEM,H-6701 SZEGED,HUNGARY

来源：

LIFE SCIENCES | 1996年 / 59卷 / 16期

基金：

匈牙利科学研究基金会;

关键词：

atrial natriuretic peptide; corticotropin-releasing factor-like immunoreactivity; brain metals;

D O I：

10.1016/0024-3205(96)00460-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have shown that ANP has anxiolytic-like effects in behavioral studies. Since CRF is thought to be involved in emotional state of the brain, the present study was undertaken to follow the possible alterations in corticotropin-releasing factor-like immunoreactivity (CRF-LI) in different regions of the brain in rats following ANP treatment. CRF-LI immunoreactivity was determined in hypothalamic and extrahypothalamic brain areas after central injection of atrial natriuretic peptide 1-28 (ANP(1-28)) in rats. After various doses of ANP(1-28) administration the CRF-LI significantly increased in the hypothalamus,the hippocampus and the frontal cortex. In the amygdala, ANP caused a marked but nonsignificant CRF-LI enhancement. In the basal forebrain, the CRF-LI decreased. These results suggest that ANP(1-28) may moderate activation of the CRF-ergic system in the brain which could be related to the neuroendocrine and behavioral action.

引用

页码：1351 / 1356

页数：6

共 27 条

[21] ALTERATIONS OF CORTICOTROPIN-RELEASING FACTOR-LIKE IMMUNOREACTIVITY IN DIFFERENT BRAIN-REGIONS AFTER ACUTE COCAINE ADMINISTRATION IN RATS [J].