Preparation of chitosan nanoparticles using methacrylic acid

被引：118

作者：

de Moura, Marcia R. ^{[1
,2
]}

Aouada, Fauze A. ^{[1
,2
]}

Mattoso, Luiz H. C. ^{[1
]}

机构：

[1] Embrapa Instrument Agropecuaria, Lab Nacl Nanotecnol Agronegocio, BR-13560970 Sao Carlos, SP, Brazil

[2] Univ Fed Sao Carlos, Dept Quim, BR-13560905 Sao Carlos, SP, Brazil

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2008年 / 321卷 / 02期

关键词：

natural polymer; biopolymer; nanoparticles formation; chitosan;

D O I：

10.1016/j.jcis.2008.02.006

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this work the preparation of chitosan nanoparticle was investigated using methacrylic acid in different conditions and studied by particle size analyzer, zeta-potential, Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) and transmission electron microscopy (TEM). The particle size was dependent on the chitosan concentration used during the preparation method. Nanoparticles with sizes as small as 60 nm were achieved, that can be extremely important for several applications. The nanoparticles solution was also pH-sensitive, due to swelling and aggregation of the nanoparticles. The nanoparticles obtained presented a very homogeneous morphology showing a quite uniform particles size distribution and a rather spherical shape. (C) 2008 Elsevier Inc. All rights reserved.

引用

收藏

页码：477 / 483

页数：7

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