Acquired hemophilia A: A concise review

被引：197

作者：

Franchini, M

Gandini, G

Di Paolantonio, T

Mariani, G

机构：

[1] Osped Policlin, Serv Immunoematol & Trasfus, Ctr Emofilia, I-37134 Verona, Italy

[2] Novo Nordisk Italia, Rome, Italy

[3] Azienda Policlin Univ, Div Ematol Trapianto, Palermo, Italy

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2005年 / 80卷 / 01期

关键词：

acquired; hemophilia; factor VIII; bleeding; treatment;

D O I：

10.1002/ajh.20390

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acquired hemophilia A is a rare but severe autoimmune bleeding disorder. It is more frequent in the elderly and results from the presence of autoantibodies directed against clotting factor VIII. In this review, we briefly report on the present state of knowledge regarding acquired hemophilia A, analyzing its epidemiology, pathogenesis, diagnostic, and clinical features. We also describe the main characteristics of this disorder according to its association with different conditions and the most important advances in the treatment of bleeding episodes and the eradication of the autoantibody.

引用

页码：55 / 63

页数：9

共 117 条

[1] Clinical efficacy of prothrombin complex concentrates and recombinant factor VIIa in the treatment of bleeding episodes in patients with factor VIII and IX inhibitors [J].