Cell and molecular biology of Notch

被引:324
作者
Fiuza, Ulla-Maj [1 ]
Arias, Alfonso Martinez [1 ]
机构
[1] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England
基金
英国惠康基金;
关键词
D O I
10.1677/JOE-07-0242
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Notch signalling is a cell-cell communication process, which allows the establishment of patterns of gene expression and differentiation, regulates binary cell fate choice and the maintenance of stern cell populations. So far, the data published has elucidated the main players in the Notch signalling pathway. However, its regulatory mechanisms are exhibiting an increasing complexity which could account for the multitude of roles it has during development and in adult organisms. In this review, we will describe the multiple roles of Notch and how various factors can regulate Notch signalling.
引用
收藏
页码:459 / 474
页数:16
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