Cell and molecular biology of Notch

被引：324

作者：

Fiuza, Ulla-Maj ^{[1
]}

Arias, Alfonso Martinez ^{[1
]}

机构：

[1] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

来源：

JOURNAL OF ENDOCRINOLOGY | 2007年 / 194卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1677/JOE-07-0242

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Notch signalling is a cell-cell communication process, which allows the establishment of patterns of gene expression and differentiation, regulates binary cell fate choice and the maintenance of stern cell populations. So far, the data published has elucidated the main players in the Notch signalling pathway. However, its regulatory mechanisms are exhibiting an increasing complexity which could account for the multitude of roles it has during development and in adult organisms. In this review, we will describe the multiple roles of Notch and how various factors can regulate Notch signalling.

引用

收藏

页码：459 / 474

页数：16

相关论文

共 144 条

[21]

deCelis JF, 1997, DEVELOPMENT, V124, P3241

[22]

Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/β-catenin but not bone morphogenetic protein signaling [J].

Deregowski, V ;

Gazzerro, E ;

Priest, L ;

Rydziel, S ;

Canalis, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (10) :6203-6210

[23]

DIEDERICH RJ, 1994, DEVELOPMENT, V120, P473

[24]

MOLECULAR-INTERACTIONS BETWEEN THE PROTEIN PRODUCTS OF THE NEUROGENIC LOCI NOTCH AND DELTA, 2 EGF-HOMOLOGOUS GENES IN DROSOPHILA [J].

FEHON, RG ;

KOOH, PJ ;

REBAY, I ;

REGAN, CL ;

XU, T ;

MUSKAVITCH, MAT ;

ARTAVANISTSAKONAS, S .

CELL, 1990, 61 (03) :523-534

[25]

Structural conservation of Notch receptors and ligands [J].

Fleming, RJ .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1998, 9 (06) :599-607

[26]

THE SUPPRESSOR OF HAIRLESS PROTEIN PARTICIPATES IN NOTCH RECEPTOR SIGNALING [J].

FORTINI, ME ;

ARTAVANISTSAKONAS, S .

CELL, 1994, 79 (02) :273-282

[27]

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage [J].

Frise, E ;

Knoblich, JA ;

YoungerShepherd, S ;

Jan, LY ;

Jan, YN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :11925-11932

[28]

Mastermind recruits CycC:CDK8 to phosphorylate the notch ICD and coordinate activation with turnover [J].

Fryer, CJ ;

White, JB ;

Jones, KA .

MOLECULAR CELL, 2004, 16 (04) :509-520

[29]

The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila [J].

Fuwa, TJ ;

Hori, K ;

Sasamura, T ;

Higgs, J ;

Baron, M ;

Matsuno, K .

MOLECULAR GENETICS AND GENOMICS, 2006, 275 (03) :251-263

[30]

Gibert JM, 2003, INT J DEV BIOL, V47, P643

← 1 2 3 4 5 6 7 8 9 10 →