Intranigral LPS Administration Produces Dopamine, Glutathione but not Behavioral Impairment in Comparison to MPTP and 6-OHDA Neurotoxin Models of Parkinson's Disease

被引：31

作者：

Ariza, Deborah ^{[1
]}

Lima, Marcelo M. S. ^{[1
]}

Moreira, Camila G. ^{[1
]}

Dombrowski, Patricia A. ^{[1
]}

Avila, Thiago V. ^{[1
]}

Allemand, Alexandra ^{[1
]}

Mendes, Daniel A. G. B. ^{[1
]}

Da Cunha, Claudio ^{[1
]}

Vital, Maria A. B. F. ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Farmacol, Setor Ciencias Biol, BR-81531990 Curitiba, PR, Brazil

来源：

NEUROCHEMICAL RESEARCH | 2010年 / 35卷 / 10期

关键词：

Neuroinflammation; Animal models; Glutathione; LPS; NIGRA PARS COMPACTA; SUBSTANTIA-NIGRA; INFLAMMATION; INJECTION; COX-2; RATS; NEURODEGENERATION; INFUSION; LESIONS; DAMAGE;

D O I：

10.1007/s11064-010-0222-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The current investigation compared intranigral lipopolysaccharide (LPS), 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) administrations, in the light of neurochemical, behavioral and endogenous antioxidant glutathione alterations. All the results were collected 1, 3 and 7 days after the lesions. LPS produced a delayed reduction of striatal dopamine, whereas homovanillic acid was drastically increased at the first time-point. Comparatively, MPTP promoted dopamine reduction 3 and 7 days with increase of homovanillic acid. Whilst, 6-OHDA generated initial increase of dopamine and homovanillic acid followed by subsequent decrease of this neurotransmitter accompanied by reductions of dopamine metabolites at the same periods. Furthermore, nigral glutathione demonstrated to be a far more sensitive target for LPS than for MPTP or 6-OHDA. Behavioral data indicated impairments induced by MPTP, 6-OHDA but not LPS. In conclusion, it is suggested that intranigral LPS can provide new insights about neuroinflammation, simulating features of the pre-motor phase of Parkinson's disease.

引用

页码：1620 / 1627

页数：8

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