Adoptive cellular immunotherapy for childhood malignancies

被引：6

作者：

Cooper, L. J. N. ^{[1
]}

机构：

[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Pediat, Houston, TX 77030 USA

来源：

BONE MARROW TRANSPLANTATION | 2008年 / 41卷 / 02期

关键词：

pediatric cancer; immunotherapy; T cells;

D O I：

10.1038/sj.bmt.1705930

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Clinical trials have established that T cells have the ability to prevent and treat pathogens and tumors. This is perhaps best exemplified by engraftment of allogeneic T cells in the context of hematopoietic stem-cell transplantation (HSCT), which for over the last 50 years remains one of the best and most robust examples of cell-based therapies for the treatment of hematologic malignancies. Yet, the approach to infuse T cells for treatment of cancer, in general, and pediatric tumors, in particular, generally remains on the sidelines of cancer therapy. This review outlines the current state-of-the-art and provides a rationale for undertaking adoptive immunotherapy trials with emphasis on childhood malignancies.

引用

页码：183 / 192

页数：10

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