Future directions for the use of hypomethylating agents

被引：19

作者：

Garcia-Manero, G

Gore, SD

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[2] Johns Hopkins Univ, Sidney Kimmel Comprehensj Canc Ctr, Baltimore, MD USA

来源：

SEMINARS IN HEMATOLOGY | 2005年 / 42卷 / 03期

关键词：

D O I：

10.1053/j.seminhematol.2005.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epigenetics refers to heritable changes in DNA and chromatin that impact gene expression without a change in DNA sequence. Two major steps involved in epigenetic regulation of gene expression include methylation of the promoter region of the gene and deacetylation of specific lysine residues on promoter-associated histones leading to changes in chromatin structure. Promoter hypermethylation is the most extensively studied epigenetic process. Our expanding knowledge of this process has led to its application in the diagnosis, prognosis, and treatment of various hematologic and neoplastic diseases. Several agents, which reverse promoter methylation or inhibit histone deacetylases, are under development for use alone or in combination for a variety of neoplastic diseases. This review discusses the potential use of methylation reversing agents in the treatment of solid tumors and in benign hematologic disorders along with the rationale for combination therapies using hypomethylating agents. © 2005 Elsevier Inc. All rights reserved.

引用

页码：S50 / S59

页数：10

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