Fighting neurodegeneration with rapamycin: mechanistic insights

被引：420

作者：

Bove, Jordi ^{[1
]}

Martinez-Vicente, Marta ^{[1
]}

Vila, Miquel ^{[1
,2
,3
]}

机构：

[1] Vall Hebron Res Inst CIBERNED, Neurodegenerat Dis Res Grp, Barcelona 08035, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain

[3] Autonomous Univ Barcelona, Dept Biochem & Mol Biol, E-08193 Barcelona, Spain

来源：

NATURE REVIEWS NEUROSCIENCE | 2011年 / 12卷 / 08期

关键词：

AMYOTROPHIC-LATERAL-SCLEROSIS; LIFE-SPAN EXTENSION; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MOUSE MODEL; LYSOSOMAL MEMBRANE PERMEABILIZATION; CAP-DEPENDENT TRANSLATION; AGGREGATE-PRONE PROTEINS; RENAL-CELL CARCINOMA; PARKINSONS-DISEASE; HUNTINGTONS-DISEASE; ALPHA-SYNUCLEIN;

D O I：

10.1038/nrn3068

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A growing number of studies point to rapamycin as a pharmacological compound that is able to provide neuroprotection in several experimental models of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease and spinocerebellar ataxia type 3. In addition, rapamycin exerts strong anti-ageing effects in several species, including mammals. By inhibiting the activity of mammalian target of rapamycin (mTOR), rapamycin influences a variety of essential cellular processes, such as cell growth and proliferation, protein synthesis and autophagy. Here, we review the molecular mechanisms underlying the neuroprotective effects of rapamycin and discuss the therapeutic potential of this compound for neurodegenerative diseases.

引用

页码：437 / 452

页数：16

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