Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

被引：204

作者：

Anisimov, Vladimir N. ^{[1
]}

Zabezhinski, Mark A. ^{[1
]}

Popovich, Irina G. ^{[1
]}

Piskunova, Tatiana S. ^{[1
]}

Semenchenko, Anna V. ^{[1
]}

Tyndyk, Margarita L. ^{[1
]}

Yurova, Maria N. ^{[1
]}

Antoch, Marina P. ^{[3
]}

Blagosklonny, Mikhail V. ^{[2
]}

机构：

[1] NN Petrov Res Inst Oncol, Dept Carcinogenesis & Oncogerontol, St Petersburg 197758, Russia

[2] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA

[3] Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2010年 / 176卷 / 05期

关键词：

TRANSGENIC MOUSE MODEL; FATAL NEOPLASTIC DISEASES; CALORIE RESTRICTION; DELAYED OCCURRENCE; MAMMALIAN TARGET; TOR; GROWTH; PROGRESSION; ONSET; MTOR;

D O I：

10.2353/ajpath.2010.091050

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Aging is associated with obesity and cancer. Calorie restriction both slows down aging and delays cancer. Evidence has emerged that the nutrient-sensing mammalian target of rapamycin (mTOR) pathway is involved in cellular and organismal aging. Here we show that the mTOR inhibitor rapamycin prevents age-related weight gain, decreases rate of aging, increases lifespan, and suppresses carcinogenesis in transgenic HER-2/neu cancer-prone mice. Rapamycin dramatically delayed tumor onset as well as decreased the number of tumors per animal and tumor size. We suggest that, by slowing down organismal aging, rapamycin delays cancer. (Am J Pathol 2010, 176:2092-2097; DOI: 10.2353/ajpath.2010.091050)

引用

页码：2092 / 2097

页数：6

共 37 条

[1] Anisimov Vladimir N, 2007, Methods Mol Biol, V371, P227
[2] Metformin slows down aging and extends life span of female SHR mice
Anisimov, Vladimir N.
Berstein, Lev M.
Egormin, Peter A.
Piskunova, Tatiana S.
Popovich, Irina G.
Zabezhinski, Mark A.
Tyndyk, Margarita L.
Yurova, Maria V.
Kovalenko, Irina G.
Poroshina, Tatiana E.
Semenchenko, Anna V.
[J]. CELL CYCLE, 2008, 7 (17) : 2769 - 2773
[3] Anisimov Vladimir N, 2007, Cancer Control, V14, P23
[4] Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
Anisimov, VN
Berstein, LM
Egormin, PA
Piskunova, TS
Popovich, IG
Zabezhinski, MA
Kovalenko, IG
Poroshina, TE
Semenchenko, AV
Provinciali, M
Re, F
Franceschi, C
[J]. EXPERIMENTAL GERONTOLOGY, 2005, 40 (8-9) : 685 - 693
[5] Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin-in aging
Bartke, A
[J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2006, 17 (02) : 33 - 35
[6] Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice
Berrigan, D
Perkins, SN
Haines, DC
Hursting, SD
[J]. CARCINOGENESIS, 2002, 23 (05) : 817 - 822
[7] Prevention of cancer by inhibiting aging
Blagosklonny, Mikhail V.
[J]. CANCER BIOLOGY & THERAPY, 2008, 7 (10) : 1520 - 1524
[8] An anti-aging drug today: from senescence-promoting genes to anti-aging pill
Blagosklonny, Mikhail V.
[J]. DRUG DISCOVERY TODAY, 2007, 12 (5-6) : 218 - 224
[9] Validation of anti-aging drugs by treating age-related diseases
Blagosklonny, Mikhail V.
[J]. AGING-US, 2009, 1 (03): : 281 - 288
[10] Calorie restriction, SIRT1 and metabolism: Understanding longevity
Bordone, L
Guarente, L
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) : 298 - 305

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