Validation of anti-aging drugs by treating age-related diseases

被引：122

作者：

Blagosklonny, Mikhail V. ^{[1
]}

机构：

[1] Ordway Res Inst, Ctr Canc, Albany, NY 12208 USA

来源：

AGING-US | 2009年 / 1卷 / 03期

关键词：

Anti-aging drugs; diseases; cancer; atherosclerosis; resveratrol; rapamycin; metformin; SMALL-MOLECULE ACTIVATORS; AKT/PROTEIN KINASE-B; EXTENDS LIFE-SPAN; P70; S6; KINASE; CARDIAC-HYPERTROPHY; CALORIE RESTRICTION; MAMMALIAN TARGET; ALZHEIMERS-DISEASE; REDUCED INCIDENCE; KAPOSIS-SARCOMA;

D O I：

10.18632/aging.100034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Humans die from age-related diseases, which are deadly manifestations of the aging process. In order to extend-life span, an anti-aging drug must delay age-related diseases. All together age-related diseases are the best biomarker of aging. Once a drug is used for treatment of any one chronic disease, its effect against other diseases (atherosclerosis, cancer, prostate enlargement, osteoporosis, insulin resistance, Alzheimer's and Parkinson's diseases, age-related macular-degeneration) may be evaluated in the same group of patients. If the group is large, then the anti-aging effect could bevalidated in a couple of years. Startlingly, retrospective analysis of clinical and preclinical data reveals four potential anti-aging modalities.

引用

页码：281 / 288

页数：8

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