Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin-in aging

被引：77

作者：

Bartke, A

机构：

[1] So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA

[2] So Illinois Univ, Sch Med, Dept Physiol, Springfield, IL 62794 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2006年 / 17卷 / 02期

关键词：

D O I：

10.1016/j.tem.2006.01.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It was recently reported by Kurosu et al. that overexpression of Klotho, a newly discovered hormone, extends longevity of mice. Because Klotho induces IGF-1 and insulin resistance, these findings appear to contradict previous evidence for increased life span of dwarf mice with reduced IGF-1 and insulin levels and enhanced insulin sensitivity. However, activation of signaling molecules downstream from IGF-1 and insulin receptors is reduced in both Klotho and dwarf mice, suggesting common mechanisms of delayed aging.

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页码：33 / 35

页数：3

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