Recognition of host immune activation by Pseudomonas aeruginosa

被引：251

作者：

Wu, LC

Estrada, O

Zaborina, O

Bains, M

Shen, L

Kohler, JE

Patel, N

Musch, MW

Chang, EB

Fu, YX

Jacobs, MA

Nishimura, MI

Hancock, REW

Turner, JR

Alverdy, JC ^{[1
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Dept Surg, Chicago, IL 60637 USA

[2] Univ Chicago, Pritzker Sch Med, Dept Pathol, Chicago, IL 60637 USA

[3] Univ Chicago, Pritzker Sch Med, Dept Med, Chicago, IL 60637 USA

[4] Univ British Columbia, Dept Immunol & Microbiol, Vancouver, BC V6T 1Z4, Canada

[5] Univ Washington, Dept Genome Sci & Med, Seattle, WA 98195 USA

来源：

SCIENCE | 2005年 / 309卷 / 5735期

关键词：

D O I：

10.1126/science.1112422

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is generally reasoned that lethal infections caused by opportunistic pathogens develop permissively by invading a host that is both physiologically stressed and immunologically compromised. However, an alternative hypothesis might be that opportunistic pathogens actively sense alterations in host immune function and respond by enhancing their virulence phenotype. We demonstrate that interferon-gamma binds to an outer membrane protein in Pseudomonas aeruginosa, OprF, resulting in the expression of a quorum-sensing dependent virulence determinant, the PA-1 lectin. These observations provide details of the mechanisms by which prokaryotic organisms are directly signaled by immune activation in their eukaryotic host.

引用

收藏

页码：774 / 777

页数：4

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