Mitochondria in cancer cells: what is so special about them?

被引：685

作者：

Gogvadze, Vladimir ^{[1
]}

Orrenius, Sten ^{[1
]}

Zhivotovsky, Boris ^{[1
]}

机构：

[1] Karolinska Inst, Inst Environm Med, Div Toxicol, SE-17177 Stockholm, Sweden

来源：

TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.tcb.2008.01.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The past decade has revealed a new role for the mitochondria in cell metabolism - regulation of cell death pathways. Considering that most tumor cells are resistant to apoptosis, one might question whether such resistance is related to the particular properties of mitochondria in cancer cells that are distinct from those of mitochondria in non-malignant cells. This scenario was originally suggested by Otto Warburg, who put forward the hypothesis that a decrease in mitochondrial energy metabolism might lead to development of cancer. This review is devoted to the analysis of mitochondrial function in cancer cells, including the mechanisms underlying the upregulation of glycolysis, and how intervention with cellular bioenergetic pathways might make tumor cells more susceptible to anticancer treatment and induction of apoptosis.

引用

页码：165 / 173

页数：9

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