Inhibitory effects of tandospirone, a 5-HT1A agonist, on medial vestibular nucleus neurons responding to lateral roll tilt stimulation in rats

被引：12

作者：

Amano, T ^{[1
]}

Akbar, M ^{[1
]}

Matsubayashi, H ^{[1
]}

Sasa, M ^{[1
]}

机构：

[1] Hiroshima Univ, Sch Med, Dept Pharmacol, Hiroshima 7348551, Japan

来源：

BRAIN RESEARCH | 2001年 / 910卷 / 1-2期

关键词：

tandospirone; WAY-100635; lateral roll tilt; 5-HT1A; medial vestibular nucleus neuron;

D O I：

10.1016/S0006-8993(01)02698-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

An electrophysiological study was performed using chloral hydrate-anesthetized rats to determine whether tandospirone, a 5-HT1A agonist, affects neuronal activities of the medial vestibular nucleus (MVN), since serotonergic innervation and 5-HT1A receptors are present in this nucleus. Tandospirone applied microiontophoretically at a current of 20-60 nA caused an inhibition of tilt-induced firing of alpha -type neurons, which showed increased and decreased firing with lateral tilt ipsilateral and contralateral to the recording site, respectively, along with that of beta -type neurons which exhibited the reverse responses to ipsilateral and contralateral tilt stimulation. The inhibition was antagonized during simultaneous, iontophoretic application of WAY-100635 (20-60 nA), a 5-HT1A receptor antagonist, although WAY-100635 alone rarely affected spontaneous or tilt-induced firing in either type of neurons. These results suggest that tandospirone acts on a 5-HT1A receptor to inhibit transmission of otolith information to alpha- and beta -type MVN neurons. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：195 / 198

页数：4

共 26 条

[1]

Effects of 5-HT1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (S)-WAY100135, but not WAY100635, has partial agonist properties [J].

Assie, MB ;

Koek, W .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 304 (1-3) :15-21

[2]

A review of central 5-HT receptors and their function [J].

Barnes, NM ;

Sharp, T .

NEUROPHARMACOLOGY, 1999, 38 (08) :1083-1152

[3]

MODIFICATION OF SYNAPTIC INPUT FOLLOWING UNILATERAL LABYRINTHECTOMY [J].

DIERINGER, N ;

PRECHT, W .

NATURE, 1977, 269 (5627) :431-433

[4]

Characterization of 5-HT1A receptor functional coupling in cells expressing the human 5-HT1A receptor as assessed with the cytosensor microphysiometer [J].

Dunlop, J ;

Zhang, YX ;

Smith, DL ;

Schechter, LE .

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1998, 40 (01) :47-55

[5]

Fletcher A, 1996, BEHAV BRAIN RES, V73, P337

[6]

A PHARMACOLOGICAL PROFILE OF THE SELECTIVE SILENT 5-HT1A RECEPTOR ANTAGONIST, WAY-100635 [J].

FORSTER, EA ;

CLIFFE, IA ;

BILL, DJ ;

DOVER, GM ;

JONES, D ;

REILLY, Y ;

FLETCHER, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 281 (01) :81-88

[7]

TANDOSPIRONE AND ITS METABOLITE, 1-(2-PYRIMIDINYL)-PIPERAZINE .1. EFFECTS OF ACUTE AND LONG-TERM ADMINISTRATION OF TANDOSPIRONE ON SEROTONIN NEUROTRANSMISSION [J].

GODBOUT, R ;

CHAPUT, Y ;

BLIER, P ;

DEMONTIGNY, C .

NEUROPHARMACOLOGY, 1991, 30 (07) :679-690

[8]

INHIBITION OF HIPPOCAMPAL CA1 NEURONS BY 5-HYDROXYTRYPTAMINE, DERIVED FROM THE DORSAL RAPHE NUCLEUS AND THE 5-HYDROXYTRYPTAMINE-1A AGONIST SM-3997 [J].

HIROSE, A ;

SASA, M ;

AKAIKE, A ;

TAKAORI, S .

NEUROPHARMACOLOGY, 1990, 29 (02) :93-101

[9]

JOHNSTON AR, 1993, EXP BRAIN RES, V93, P293

[10]

INVOLVEMENT OF THE DORSAL HIPPOCAMPUS IN MEDIATION OF THE ANTIANXIETY ACTION OF TANDOSPIRONE, A 5-HYDROXYTRYPTAMINE1A AGONISTIC ANXIOLYTIC [J].

KATAOKA, Y ;

SHIBATA, K ;

MIYAZAKI, A ;

INOUE, Y ;

TOMINAGA, K ;

KOIZUMI, S ;

UEKI, S .

NEUROPHARMACOLOGY, 1991, 30 (05) :475-480

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