Evidence for gas-phase redox chemistry inducing novel fragmentation in a complex natural product

被引：16

作者：

Lopes, NP

Stark, CBW

Staunton, J

Gates, PJ

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

[3] Free Univ Berlin, Inst Chem Organ Chem, D-1000 Berlin, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 03期

关键词：

D O I：

10.1039/b311871a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The fragmentation of monensin A, in the presence of calcium, barium, silver and copper salts was studied by electrospray ionisation tandem accurate-mass mass spectrometry. The results showed that the calcium, barium and silver complexes of monensin A showed no significant alteration in their fragmentation to that previously observed for the sodium salts. However, the fragmentation of the copper(II) salt resulted in new fragmentation routes. We propose that the copper might be initiating a novel gas-phase redox reaction resulting in a series of highly diagnostic ions. This methodology is demonstrated by locating the change in structure between the naturally occurring analogues monensin A and B.

引用

页码：358 / 363

页数：6

共 23 条

[11]

Kiehl DE, 1998, RAPID COMMUN MASS SP, V12, P903, DOI 10.1002/(SICI)1097-0231(19980731)12:14<903::AID-RCM253>3.0.CO

[12]

2-V

[13]

Kim YH, 1996, J MASS SPECTROM, V31, P855, DOI 10.1002/(SICI)1096-9888(199608)31:8<855::AID-JMS363>3.3.CO

[14]

2-L