Sex hormone-binding globulin and type 2 diabetes mellitus

被引：129

作者：

Le, Trang N. ^{[1
]}

Nestler, John E. ^{[2
,3
]}

Strauss, Jerome F., III ^{[3
,4
]}

Wickham, Edmond P., III ^{[1
,2
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Pediat, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Sch Med, Inst Womens Hlth, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ, Sch Med, Dept Obstet & Gynecol, Richmond, VA 23298 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 01期

基金：

美国国家卫生研究院;

关键词：

POLYCYSTIC-OVARY-SYNDROME; ADDITIONAL CARBOHYDRATE CHAIN; FATTY LIVER-DISEASE; HUMAN-BLOOD-PLASMA; MIDDLE-AGED MEN; METABOLIC SYNDROME; INSULIN-RESISTANCE; CELL-LINE; MEMBRANE-RECEPTOR; GENE-EXPRESSION;

D O I：

10.1016/j.tem.2011.09.005

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic and environmental factors that potentially contribute to the pathophysiology of type 2 diabetes mellitus (T2DM). In addition to epidemiologic studies demonstrating a consistent relationship between decreased levels of serum SHBG and incident T2DM, recent genetic studies also reveal that transmission of specific polymorphisms in the SHBG gene influence the risk of T2DM. At the molecular level, the multiple interactions between SHBG and its receptors in various target tissues suggest physiologic roles for SHBG that are more complex than the simple transport of sex hormones in serum. Taken together, these data provide support for an expanded role of SHBG in the pathophysiology of insulin resistance and T2DM.

引用

页码：32 / 40

页数：9

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