Angiogenic response induced by acellular femoral matrix in vivo

被引：21

作者：

Conconi, MT

Nico, B

Rebuffat, P

Crivellato, E

Parnigotto, PP

Nussdorfer, GG

Ribatti, D

机构：

[1] Univ Padua, Dept Pharmaceut Sci, I-35100 Padua, Italy

[2] Univ Bari, Sch Med, Dept Human Anat & Histol, I-70121 Bari, Italy

[3] Univ Padua, Sch Med, Dept Human Anat & Physiol, Sect Anat, I-35100 Padua, Italy

[4] Univ Udine, Sch Med, Dept Med & Morphol Res, Sect Anat, I-33100 Udine, Italy

来源：

JOURNAL OF ANATOMY | 2005年 / 207卷 / 01期

关键词：

acellular matrices; angiogenesis; chorioallantoic membrane; femur; fibroblast growth factor-2; transforming growth factor-beta;

D O I：

10.1111/j.1469-7580.2005.00427.x

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 [人体解剖与组织胚胎学];

摘要：

We investigated the angiogenic response induced by acellular femoral matrices implanted in vivo on to the chick embryo chorioallantoic membrane (CAM), a useful model for such investigation. The results showed that acellular matrices were able to induce a strong angiogenic response, comparable with that of fibroblast growth factor-2 (FGF-2), a well-known angiogenic cytokine. The angiogenic response was further increased when exogenous FGF-2 or transforming growth factor beta-1 (TGF-beta 1) was added to the matrices and inhibited by the addition of anti-FGF-2 or anti-TGF-beta 1 antibodies. The response may be considered to be dependent on a direct angiogenic effect exerted by the matrices, and also in part by the presence of FGF-2 and TGF-beta 1 in the acellular matrices.

引用

页码：79 / 83

页数：5

共 23 条

[1]

Construction of autologous human heart valves based on an acellular allograft matrix [J].