Detailed visualization of the anterior segment using Fourier-domain optical coherence tomography

Objective: To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities. Methods: A high-speed anterior segment optical coherence tomography prototype was developed using a 1310-nm-wavelength swept light source. Six healthy subjects and 6 patients with glaucoma were imaged in an observational cross-sectional study. Results: Schlemm's canal and the trabecular meshwork were visualized in all of the patients. Fifteen-millimeter scans enabled entire anterior segment visualization providing configuration details of the iris with respect to the angle. Four-millimeter scans permitted detailed views of the angle configuration and its structures. Volumetric imaging was possible and Schlemm's canal was visualized along part of its circumference. Conclusion: Anterior segment Fourier-domain optical coherence tomography permits detailed noncontact imaging of the angle and its structures, providing a tool to improve our understanding of the pathogenesis of narrow-angle glaucoma.