Rapid access to polyketide scaffolds via vinylogous Mukaiyama aldol reactions

被引：52

作者：

Hassfeld, J ^{[1
]}

Christmann, M ^{[1
]}

Kalesse, M ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 22期

关键词：

D O I：

10.1021/ol016677o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The use of the Z-configured vinylogous silyl ketene acetals in Mukaiyama aldol reactions is described. Isopropyl alcohol as scavanger and the use of tris(pentafluorophenyl)borane as the Lewis acid are required for obtaining the gamma -alkylated syn-product selectively. In cases of a-chiral aldehydes, Felkin-Anh selectivity was observed.

引用

页码：3561 / 3564

页数：4

共 32 条

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