A question of balance: The role of cyclin-kinase inhibitors in development and tumorigenesis

被引:115
作者
Elledge, SJ [1 ]
Winston, J [1 ]
Harper, JW [1 ]
机构
[1] BAYLOR COLL MED, HOWARD HUGHES MED INST, HOUSTON, TX 77030 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0962-8924(96)10030-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cyclin-kinase inhibitors (CKIs) are versatile negative regulators of cell proliferation that function in developmental decisions, checkpoint control and tumour suppression. Phenotypic examination of mice lacking individual CKIs has begun to reveal the specialized roles that each of these proteins play in vivo. This review focuses on what has been learned about the role of CKIs in development and cancer through the generation of knockout animals. The authors discuss whether differences in knockout phenotypes between CKIs reflect differential use of these inhibitors by the organism or a fundamental difference between the inhibitors, and suggest a balance hypothesis to explain the different effects observed.
引用
收藏
页码:388 / 392
页数:5
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