Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029

被引：49

作者：

Dong, Jin Yan ^{[1
,2
]}

Song, Hong Chuan ^{[3
]}

Li, Jian Hua ^{[3
]}

Tang, Yu Shu ^{[3
]}

Sun, Rong ^{[3
]}

Wang, Le ^{[1
,2
]}

Zhou, Yong Ping ^{[1
,2
]}

Wang, Li Mei ^{[1
,2
]}

Shen, Kai Ze ^{[1
,2
]}

Wang, Chun Ren ^{[3
]}

Zhang, Ke-Qin ^{[1
,2
]}

机构：

[1] Yunnan Univ, Lab Conservat & Utilizat Bioresources, Kunming 650091, Peoples R China

[2] Yunnan Univ, Chinese Minist Educ, Key Lab Microbial Resources, Kunming 650091, Peoples R China

[3] Yunnan Normal Univ, Provincial Key Lab Rural Energy Engn, Kunming 650092, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 06期

关键词：

D O I：

10.1021/np800034g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new preussomerin analogues, ymf 1029A (1), B (2), C (3), D (4), and E (5), were isolated from the liquid cultures of an unidentified freshwater fungus YMF 1.01029, along with four known compounds, preussomerin C (6), preussomerin D (7), (4RS)- 4,8-dihydroxy-3,4-dihydronaphthalen-1 (2H)-one (8), and 4,6,8-trihydroxy-3,4-dihydronaphthalen-1 (2H)one (9). The structures of new metabolites were determined by analysis of NMR and MS data and by analogy with the data for the known bis-spirobisnaphthalene preussomerins. In vitro immersion experiments showed that these metabolites displayed weak nematicidal activity against Bursaphelenchus xylophilus, while compound 7 was the most potent. This is the first report of these compounds, which antagonize the Bursaphelenchus xylophilus nematode.

引用

页码：952 / 956

页数：5

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