Comparison of Everolimus- and Sirolimus-Eluting Stents in Patients With Long Coronary Artery Lesions A Randomized LONG-DES-III (Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-III) Trial

被引：50

作者：

Park, Duk-Woo

Kim, Young-Hak

Song, Hae-Geun

Ahn, Jung-Min

Kim, Won-Jang

Lee, Jong-Young

Kang, Soo-Jin

Lee, Seung-Whan

Lee, Cheol Whan

Park, Seong-Wook

Yun, Sung-Cheol ^{[2
]}

Seung, Ki-Bae ^{[3
]}

Yang, Tae-Hyun ^{[4
]}

Lee, Sang-Gon ^{[5
]}

Lee, Jae-Hwan ^{[6
]}

Seong, In-Whan ^{[6
]}

Cheong, Sang-Sig ^{[7
]}

Lee, Bong-Ki ^{[8
]}

Lee, Nae-Hee ^{[9
]}

Lee, Se-Whan ^{[10
]}

Lee, Seung-Wook ^{[11
]}

Lee, Keun ^{[12
]}

Kim, Hyun-Sook ^{[13
]}

Jeon, Doo-Soo ^{[14
]}

Kim, Min-Kyu ^{[15
]}

Nah, Deuk-Young ^{[16
]}

Tahk, Seung-Jea ^{[17
]}

Park, Seung-Jung ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Dept Cardiol, Cardiac Ctr,Asan Med Ctr, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Ctr Med Res & Informat, Div Biostat,Asan Med Ctr, Seoul 138736, South Korea

[3] Catholic Univ Korea, St Marys Hosp, Seoul, South Korea

[4] Inje Univ, Pusan Paik Hosp, Pusan, South Korea

[5] Ulsan Univ Hosp, Ulsan, South Korea

[6] Chungnam Natl Univ Hosp, Taejon, South Korea

[7] GangNeung Asan Med Ctr, Kangnung, South Korea

[8] Kangwon Natl Univ Hosp, Chunchon, South Korea

[9] Soonchunhyang Univ, Bucheon Hosp, Puchon, South Korea

[10] Soon Chun Hyang Univ, Cheonan Hosp, Cheonan, South Korea

[11] Kwangju Christian Hosp, Kwangju, South Korea

[12] Seoul Vet Hosp, Seoul, South Korea

[13] Hallym Univ, Sacred Heart Hosp, Anyang, South Korea

[14] Catholic Univ Korea, St Marys Hosp, Inchon, South Korea

[15] Hallym Univ, Sacred Heart Hosp, Seoul, South Korea

[16] Donguk Univ, Gyeongju Hosp, Gyeongju, South Korea

[17] Ajou Univ, Med Ctr, Suwon 441749, South Korea

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2011年 / 4卷 / 10期

关键词：

angioplasty; coronary disease; stents; BARE-METAL; RESTENOSIS; DISEASE; THROMBOSIS;

D O I：

10.1016/j.jcin.2011.05.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives This study compared everolimus-eluting stents (EES) and sirolimus-eluting stents (SES) for long coronary lesions. Background Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. Methods This randomized, multicenter, prospective trial compared the use of long EES with SES in 450 patients with long (>= 25 mm) native coronary lesions. The primary endpoint of the trial was insegment late luminal loss at 9-month angiographic follow-up. Results The EES and SES groups had similar baseline characteristics. Lesion length was 34.0 +/- 15.4 mm in the EES group and 34.3 +/- 13.5 mm in the SES group (p = 0.85). Nine-month angiographic follow-up was performed in 80% of the EES group and 81% of the SES group (p = 0.69). In-segment late loss as the primary study endpoint was significantly larger in the EES group than in the SES group (0.17 +/- 0.41 mm vs. 0.09 +/- 0.30 mm, p for noninferiority = 0.96, p for superiority = 0.04). The in-segment binary restenosis rate was also higher in the EES group than in the SES group (7.3% vs. 2.7%, p = 0.046). However, in-stent late loss (0.22 +/- 0.43 mm vs. 0.18 +/- 0.28 mm, p = 0.29) and in-stent binary restenosis rate (3.9% vs. 2.7%, p = 0.53) were similar among the 2 groups. The incidence of any clinical outcomes (death, myocardial infarction, stent thrombosis, target lesion revascularization, and composite outcomes) was not statistically different between the 2 groups. Conclusions For patients with long native coronary artery disease, EES implantation was associated with greater angiographic in-segment late loss and higher rates of in-segment restenosis compared with SES implantation. However, clinical outcomes were both excellent and not statistically different (Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-III [LONG-DES-III]; NCT01078038) (J Am Coll Cardiol Intv 2011;4:1096-103) (C) 2011 by the American College of Cardiology Foundation

引用

页码：1096 / 1103

页数：8

共 21 条

[11] Quantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation [J].

Lansky, AJ ;

Dangas, G ;

Mehran, R ;

Desai, KJ ;

Mintz, GS ;

Wu, HS ;

Fahy, M ;

Stone, GW ;

Waksman, R ;

Leon, MB .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (02) :274-280

[12]

Laskey WK, 2007, CIRCULATION, V115, P2352, DOI 10.1161/CIRCULATIONAHA.107.688416

[13] A comparison of bare-metal and drug-eluting stents for off-label indications [J].

Marroquin, Oscar C. ;

Selzer, Faith ;

Mulukutla, Suresh R. ;

Williams, David O. ;

Vlachos, Helen A. ;

Wilensky, Robert L. ;

Tanguay, Jean-Francois ;

Holper, Elizabeth M. ;

Abbott, J. Dawn ;

Lee, Joon S. ;

Smith, Conrad ;

Anderson, William D. ;

Kelsey, Sheryl F. ;

Kip, Kevin E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (04) :342-352

[14] Relationship of late loss in lumen diameter to coronary restenosis in sirolimus-eluting stents [J].

Mauri, L ;

Orav, EJ ;

O'Malley, AJ ;

Moses, JW ;

Leon, MB ;

Holmes, DR ;

Teirstein, PS ;

Schofer, J ;

Breithardt, G ;

Cutlip, DE ;

Kereiakes, DJ ;

Shi, CX ;

Firth, BG ;

Donohoe, DJ ;

Kuntz, RE .

CIRCULATION, 2005, 111 (03) :321-327

[15]

Mehran R, 1997, CIRCULATION, V96, P2183

[16] Comparison of Zotarolimus-Eluting Stents With Sirolimus- and Paclitaxel-Eluting Stents for Coronary Revascularization The ZEST (Comparison of the Efficacy and Safety of Zotarolimus-Eluting Stent with Sirolimus-Eluting and PacliTaxel-Eluting Stent for Coronary Lesions) Randomized Trial [J].

Park, Duk-Woo ;

Kim, Young-Hak ;

Yun, Sung-Cheol ;

Kang, Soo-Jin ;

Lee, Seung-Whan ;

Lee, Cheol-Whan ;

Park, Seong-Wook ;

Seong, In-Whan ;

Lee, Jae-Hwan ;

Tahk, Seung-Jea ;

Jeong, Myung-Ho ;

Jang, Yangsoo ;

Cheong, Sang-Sig ;

Yang, Joo-Young ;

Lim, Do-Sun ;

Seung, Ki-Bae ;

Chae, Jei-Keon ;

Hur, Seung-Ho ;

Lee, Sang-Gon ;

Yoon, Junghan ;

Lee, Nae-Hee ;

Choi, Young-Jin ;

Kim, Hyun-Sook ;

Kim, Kee-Sik ;

Kim, Hyo-Soo ;

Hong, Taeg-Jong ;

Park, Hun-Sik ;

Park, Seung-Jung .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (15) :1187-1195

[17] Angiographic surrogate end points in drug-eluting stent trials - A systematic evaluation based on individual patient data from 11 randomized, controlled trials [J].

Pocock, Stuart J. ;

Lansky, Alexandra J. ;

Mehran, Roxana ;

Popma, Jeffrey J. ;

Fahy, Martin P. ;

Na, Yingbo ;

Dangas, George ;

Moses, Jeffirey W. ;

Pucelikova, Tereza ;

Kandzari, David E. ;

Ellis, Stephen G. ;

Leon, Martin B. ;

Stone, Gregg W. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (01) :23-32

[18]

Serruys Patrick W, 2006, EuroIntervention, V2, P286

[19] Outcomes associated with drug-eluting and bare-metal stents:: a collaborative network meta-analysis [J].

Stettler, Christoph ;

Wandel, Simon ;

Allemann, Sabin ;

Kastrati, Adnan ;

Morice, Marie Claude ;

Schoemig, Albert ;

Pfisterer, Matthias E. ;

Stone, Gregg W. ;

Leon, Martin B. ;

Suarez de Lezo, Jose ;

Goy, Jean Jacques ;

Park, Seung-Jung ;

Sabate, Manel ;

Suttorp, Maarten J. ;

Kelbaek, Henning ;

Spaulding, Christian ;

Menichelli, Maurizio ;

Vermeersch, Paul ;

Dirksen, Maurits T. ;

Cervinka, Pavel ;

Petronio, Anna Sonia ;

Nordmann, Alain J. ;

Diem, Peter ;

Meier, Bernhard ;

Zwahlen, Marcel ;

Reichenbach, Stephan ;

Trelle, Sven ;

Windecker, Stephan ;

Jueni, Peter .

LANCET, 2007, 370 (9591) :937-948

[20] Comparison of an everolimus-eluting stent and a paclitaxel-eluting stent in patients with coronary artery disease - A randomized trial [J].

Stone, Gregg W. ;

Midei, Mark ;

Newman, William ;

Sanz, Mark ;

Hermiller, James B. ;

Williams, Jerome ;

Farhat, Naim ;

Mahaffey, Kenneth W. ;

Cutlip, Donald E. ;

Fitzgerald, Peter J. ;

Sood, Poornima ;

Su, Xiaolu ;

Lansky, Alexandra J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (16) :1903-1913

← 1 2 3 →