A general, two-directional synthesis of C-(1→6)-linked disaccharide mimetics:: synthesis from non-carbohydrate based starting materials

被引：15

作者：

Harding, M ^{[1
]}

Nelson, A ^{[1
]}

机构：

[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 08期

关键词：

D O I：

10.1039/b101196k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantiomerically enriched diol 1,4-di(furan-2-yl)butane-1,4-diol (R,R)-1, synthesised either by Sharpless kinetic resolution or asymmetric reduction of the corresponding diketone, was a key intermediate in the stereodivergent synthesis of diastereoisomeric C-(1 -->6)-linked disaccharides. Two-directional stereoselective functionalisation steps, for example syn- and/or anti-selective dihydroxylation reactions, were exploited in the stereoselective synthesis of five diastereoisomeric C-linked disaccharides.

引用

页码：695 / 696

页数：2

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