Synthetic studies on ecteinascidin 743: rapid access to the fully functionalized tetrahydroisoquinoline with a bridged 10-membered sulfur containing macrocycle

被引：30

作者：

De Paolis, M ^{[1
]}

Chiaroni, A ^{[1
]}

Zhu, JP ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 23期

关键词：

D O I：

10.1039/b309824a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of tetrahydroisoquinoline with a 1,4- bridged 10- membered sulfur containing macrolactone ( 5) is described. Phenolic aldolisation, Pictet - Spengler cyclisation of an acid sensitive amino diol under newly developed conditions ( LiBr, toluene - TFE, 80 degrees C) and acid promoted intramolecular C - S bond formation leading to a 10- membered cycle are key steps of our synthesis.

引用

页码：2896 / 2897

页数：2

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