Electroconducting polymers for the construction of DNA or peptide arrays on silicon chips

被引：52

作者：

Livache, T

Bazin, H

Caillat, P

Roget, A

机构：

[1] CIS Bioint, DIVT, F-30203 Bagnols Ceze, France

[2] CEA Grenoble, LETI, F-38054 Grenoble 9, France

[3] Univ Grenoble 1, CNRS, CEA,LEMSI,UMR 5819,CEA Grenoble, Dept Rech Fondamentale Mat Condensee, F-38054 Grenoble 9, France

来源：

BIOSENSORS & BIOELECTRONICS | 1998年 / 13卷 / 06期

关键词：

DNA array; peptide array; polypyrrole; silicon chip; microelectrodes;

D O I：

10.1016/S0956-5663(98)00018-9

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We wish to show in this paper new developments and new applications of the pyrrole copolymerization process allowing the addressing of pyrrole-modified biomolecules on microelectrode arrays. Two main developments are described: the first one concerns the development of multiplexed silicon chips bearing 128 microelectrodes instead of 48 for the passive chips. The second one deals with new applications of this grafting process concerning not only DNA chips but peptide chips too. In this way, copolymerization of pyrrole peptides on the chip (leading to peptide chip) and their immunological detection is illustrated. This technology shows a high dimensional resolution and a real versatility. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：629 / 634

页数：6

共 15 条

[1] High-density oligonucleotide arrays [J].