Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex

被引：57

作者：

Han, Q

Zhao, Q

Fish, S

Simonsen, KB

Vourloumis, D

Froelich, JM

Wall, D

Hermann, T

机构：

[1] Anadys Pharmacet Inc, Dept Struct Chem, San Diego, CA 92121 USA

[2] Anadys Pharmacet Inc, Dept Med Chem, San Diego, CA 92121 USA

[3] Anadys Pharmacet Inc, Dept Microbiol, San Diego, CA 92121 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 18期

关键词：

antibiotics; glycosides; molecular recognition; RNA; structure-activity relationships;

D O I：

10.1002/anie.200500028

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) In the groove: The crystal structure of the bacterial decoding-site RNA in a complex with the antibiotic apramycin reveals how glycoside scaffolds participate in RNA recognition by natural products through the formation of pseudo base pairs and triples. The structure suggests that the inhibitory action of apramycin is based on interaction of the antibiotic with ribosomal protein S12 (see structural model), a control element of ribosome translocation. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：2694 / 2700

页数：7

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