RPE lipofuscin and its role in retinal-pathobiology

被引：490

作者：

Sparrow, JR

Boulton, M

机构：

[1] Columbia Univ, Dept Ophthalmol, New York, NY 10032 USA

[2] Cardiff Univ, Dept Optometry & Vis Sci, Cardiff, S Glam, Wales

来源：

EXPERIMENTAL EYE RESEARCH | 2005年 / 80卷 / 05期

关键词：

lipofuscin; A2E; age-related macular degeneration; retinal pigment epithelial cell; light damage; photooxidation;

D O I：

10.1016/j.exer.2005.01.007

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Emerging evidence indicates that the autofluorescent pigments that accumulate as lipofuscin in retinal pigment epithelial (RPE) cells may reach levels that contribute to a decline in cell function. Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：595 / 606

页数：12

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