Synthesis of alkaloid natural products using solid-supported reagents and scavengers

被引:24
作者
Baxendale, IR [1 ]
Ley, SV [1 ]
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
关键词
D O I
10.2174/138527205774370513
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Supported reagents and scavengers have become key tools for the synthesis of biologically important molecular entities. The complexity of the target molecules attainable and the synthetic flexibility afforded by these systems now rivals any solution phase approach whilst offering the added advantage of rapid purification and work-up. This short review highlights the application of these immobilized reagents to the preparation of alkaloid natural products.
引用
收藏
页码:1521 / 1534
页数:14
相关论文
共 130 条
  • [1] NICOTINE-INDUCED PROTECTION OF CULTURED CORTICAL-NEURONS AGAINST N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED GLUTAMATE CYTOTOXICITY
    AKAIKE, A
    TAMURA, Y
    YOKOTA, T
    SHIMOHAMA, S
    KIMURA, J
    [J]. BRAIN RESEARCH, 1994, 644 (02) : 181 - 187
  • [2] RECENT DEVELOPMENTS IN THE APPLICATION OF FUNCTIONALIZED POLYMERS IN ORGANIC-SYNTHESIS
    AKELAH, A
    SHERRINGTON, DC
    [J]. POLYMER, 1983, 24 (11) : 1369 - 1386
  • [3] APPLICATION OF FUNCTIONALIZED POLYMERS IN ORGANIC-SYNTHESIS
    AKELAH, A
    SHERRINGTON, DC
    [J]. CHEMICAL REVIEWS, 1981, 81 (06) : 557 - 587
  • [4] Enantioselective approach to 7-azabicyclo[2.2.1]heptane ring systems using D-(-)-quinic acid as the chiral educt: Application to the formal synthesis of (+)-epibatidine
    Albertini, E
    Barco, A
    Benetti, S
    DeRisi, C
    Pollini, GP
    Zanirato, V
    [J]. TETRAHEDRON LETTERS, 1997, 38 (04) : 681 - 684
  • [5] TOTAL SYNTHESIS OF (+/-)-EPIBATIDINE
    ALBERTINI, E
    BARCO, A
    BENETTI, S
    DERISI, C
    POLLINI, GP
    ROMAGNOLI, R
    ZANIRATO, V
    [J]. TETRAHEDRON LETTERS, 1994, 35 (49) : 9297 - 9300
  • [6] CYTOTOXICITY OF HYMENOCALLIS-EXPANSA ALKALOIDS
    ANTOUN, MD
    MENDOZA, NT
    RIOS, YR
    PROCTOR, GR
    WICKRAMARATNE, DBM
    PEZZUTO, JM
    KINGHORN, AD
    [J]. JOURNAL OF NATURAL PRODUCTS, 1993, 56 (08): : 1423 - 1425
  • [7] Total synthesis of (-)-epibatidine using an asymmetric Diels-Alder reaction with a chiral N-acylnitroso dienophile
    Aoyagi, S
    Tanaka, R
    Naruse, M
    Kibayashi, C
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (23) : 8397 - 8406
  • [8] POTENTIAL TREATMENT OF ALZHEIMER-DISEASE USING CHOLINERGIC CHANNEL ACTIVATORS (CHCAS) WITH COGNITIVE ENHANCEMENT, ANXIOLYTIC-LIKE, AND CYTOPROTECTIVE PROPERTIES
    ARNERIC, SP
    SULLIVAN, JP
    DECKER, MW
    BRIONI, JD
    BANNON, AW
    BRIGGS, CA
    DONNELLYROBERTS, D
    RADEK, RJ
    MARSH, KC
    KYNCL, J
    WILLIAMS, M
    BUCCAFUSCO, JJ
    [J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1995, 9 : 50 - 61
  • [9] Avenoza A, 1998, SYNTHESIS-STUTTGART, P1335
  • [10] BALANDRIN MF, 1993, ACS SYM SER, V534, P2