Sensing pathogens and tuning immune responses

被引：363

作者：

Pulendran, B ^{[1
]}

Palucka, K ^{[1
]}

Banchereau, J ^{[1
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA

来源：

SCIENCE | 2001年 / 293卷 / 5528期

关键词：

D O I：

10.1126/science.1062060

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The immune system is capable of making qualitatively distinct responses against different microbial infections, and recent advances are starting to reveal how it manages this complex task. An integral component of the immune system is a network of cells known 65 dendritic cells (DCs), which sense different microbial stimuli and convey this information to Lymphocytes. A better understanding of DC biology has allowed a model to be constructed in which the type of immune response to an infection is viewed as a function of several determinants, including the subpopulation of DCs, the nature of the microbe, microbe recognition receptors, and the cytokine microenvironment.

引用

收藏

页码：253 / 256

页数：4

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