Deregulated TGF-β signaling in leukemogenesis

被引:41
作者
Lin, HK [1 ]
Bergmann, S [1 ]
Pandolfi, PP [1 ]
机构
[1] Sloan Kettering Inst, Mem Sloan Kettering Canc Ctr, Dept Pathol, Canc Biol & Genet Program, New York, NY 10021 USA
基金
美国国家卫生研究院;
关键词
TGF-beta; cPML; SARA; Smad2/3; PML-RAR alpha;
D O I
10.1038/sj.onc.1208923
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cellular homeostasis is tightly controlled by the various pathways that regulate cell proliferation and cell death. Breaking this balance is often associated with cancer development. The transforming growth factor-beta (TGF-beta) pathway plays an important role in cellular homeostasis by regulating cell growth inhibition, cellular senescence, differentiation and apoptosis. Deregulated TGF-beta signaling is known to be involved in a variety of human cancers, including those of the colon, pancreas, breast and prostate. While TGF-beta is a potent negative regulator of hematopoiesis, the role of aberrant TGF-beta signaling in leukemogenesis remains largely unknown. Recently, evidence demonstrating deregulated TGF-beta signaling in leukemogenesis, particularly in acute promyelocytic leukemia (APL), has started to emerge. In this review, we summarize the current progress towards the understanding of the molecular mechanisms by which aberrant TGF-beta signaling may participate in leukemogenesis.
引用
收藏
页码:5693 / 5700
页数:8
相关论文
共 65 条
[31]   Cell biology - An unexpected social servant [J].
Le Roy, C ;
Wrana, JL .
NATURE, 2004, 431 (7005) :142-142
[32]   Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene, PML [J].
Le, XF ;
Yang, P ;
Chang, KS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (01) :130-135
[33]   Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34(+) hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia [J].
LeBousseKerdiles, MC ;
Chevillard, S ;
Charpentier, A ;
Romquin, N ;
Clay, D ;
SmadjaJoffe, F ;
Praloran, V ;
Dupriez, B ;
Demory, JL ;
Jasmin, C ;
Martyre, MC .
BLOOD, 1996, 88 (12) :4534-4546
[34]   Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-β signaling by blocking the association of smad proteins with smad-binding element [J].
Lee, DK ;
Kim, BC ;
Brady, JN ;
Jeang, KT ;
Kim, SJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (37) :33766-33775
[35]   Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation [J].
Legler, DF ;
Micheau, O ;
Doucey, MA ;
Tschopp, J ;
Bron, C .
IMMUNITY, 2003, 18 (05) :655-664
[36]   Cytoplasmic PML function in TGF-β signalling [J].
Lin, HK ;
Bergmann, S ;
Pandolfi, PP .
NATURE, 2004, 431 (7005) :205-211
[37]   Ski/Sno and TGF-β signaling [J].
Liu, XD ;
Sun, Y ;
Weinberg, RA ;
Lodish, HF .
CYTOKINE & GROWTH FACTOR REVIEWS, 2001, 12 (01) :1-8
[38]   Snail family members and cell survival in physiological and pathological cleft palates [J].
Martínez-Alvarez, C ;
Blanco, MJ ;
Pérez, R ;
Rabadán, MA ;
Aparicio, M ;
Resel, E ;
Martínez, T ;
Nieto, MA .
DEVELOPMENTAL BIOLOGY, 2004, 265 (01) :207-218
[39]   TGFβ signaling in growth control, cancer, and heritable disorders [J].
Massagué, J ;
Blain, SW ;
Lo, RS .
CELL, 2000, 103 (02) :295-309
[40]   Molecular mechanisms of leukemogenesis by AML1/EVI-1 [J].
Mitani, K .
ONCOGENE, 2004, 23 (24) :4263-4269